Macropinocytosis confers resistance to therapies targeting cancer anabolism
Identifieur interne : 000117 ( an2020/Analysis ); précédent : 000116; suivant : 000118Macropinocytosis confers resistance to therapies targeting cancer anabolism
Auteurs : Vaishali Jayashankar ; Aimee L. EdingerSource :
- Nature Communications [ 2041-1723 ] ; 2020.
Abstract
Macropinocytic cancer cells scavenge amino acids from extracellular proteins. Here, we show that consuming necrotic cell debris via macropinocytosis (necrocytosis) offers additional anabolic benefits. A click chemistry-based flux assay reveals that necrocytosis provides not only amino acids, but sugars, fatty acids and nucleotides for biosynthesis, conferring resistance to therapies targeting anabolic pathways. Indeed, necrotic cell debris allow macropinocytic breast and prostate cancer cells to proliferate, despite fatty acid synthase inhibition. Standard therapies such as gemcitabine, 5-fluorouracil (5-FU), doxorubicin and gamma-irradiation directly or indirectly target nucleotide biosynthesis, creating stress that is relieved by scavenged nucleotides. Strikingly, necrotic debris also render macropinocytic, but not non-macropinocytic, pancreas and breast cancer cells resistant to these treatments. Selective, genetic inhibition of macropinocytosis confirms that necrocytosis both supports tumor growth and limits the effectiveness of 5-FU in vivo. Therefore, this study establishes necrocytosis as a mechanism for drug resistance.
Url:
DOI: 10.1038/s41467-020-14928-3
PubMed: 32111826
PubMed Central: 7048872
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000155
- to stream Pmc, to step Curation: 000155
- to stream Pmc, to step Checkpoint: 000110
- to stream Ncbi, to step Merge: 000F80
- to stream Ncbi, to step Curation: 000F80
- to stream Ncbi, to step Checkpoint: 000F80
- to stream Main, to step Merge: 000117
- to stream Main, to step Curation: 000117
- to stream Main, to step Exploration: 000117
- to stream an2020, to step Extraction: 000117
Links to Exploration step
PMC:7048872Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Macropinocytosis confers resistance to therapies targeting cancer anabolism</title><author><name sortKey="Jayashankar, Vaishali" sort="Jayashankar, Vaishali" uniqKey="Jayashankar V" first="Vaishali" last="Jayashankar">Vaishali Jayashankar</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Edinger, Aimee L" sort="Edinger, Aimee L" uniqKey="Edinger A" first="Aimee L." last="Edinger">Aimee L. Edinger</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32111826</idno><idno type="pmc">7048872</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048872</idno><idno type="RBID">PMC:7048872</idno><idno type="doi">10.1038/s41467-020-14928-3</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000155</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000155</idno><idno type="wicri:Area/Pmc/Curation">000155</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000155</idno><idno type="wicri:Area/Pmc/Checkpoint">000110</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000110</idno><idno type="wicri:Area/Ncbi/Merge">000F80</idno><idno type="wicri:Area/Ncbi/Curation">000F80</idno><idno type="wicri:Area/Ncbi/Checkpoint">000F80</idno><idno type="wicri:Area/Main/Merge">000117</idno><idno type="wicri:Area/Main/Curation">000117</idno><idno type="wicri:Area/Main/Exploration">000117</idno><idno type="wicri:Area/an2020/Extraction">000117</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Macropinocytosis confers resistance to therapies targeting cancer anabolism</title><author><name sortKey="Jayashankar, Vaishali" sort="Jayashankar, Vaishali" uniqKey="Jayashankar V" first="Vaishali" last="Jayashankar">Vaishali Jayashankar</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Edinger, Aimee L" sort="Edinger, Aimee L" uniqKey="Edinger A" first="Aimee L." last="Edinger">Aimee L. Edinger</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Nature Communications</title><idno type="eISSN">2041-1723</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Macropinocytic cancer cells scavenge amino acids from extracellular proteins. Here, we show that consuming necrotic cell debris via macropinocytosis (necrocytosis) offers additional anabolic benefits. A click chemistry-based flux assay reveals that necrocytosis provides not only amino acids, but sugars, fatty acids and nucleotides for biosynthesis, conferring resistance to therapies targeting anabolic pathways. Indeed, necrotic cell debris allow macropinocytic breast and prostate cancer cells to proliferate, despite fatty acid synthase inhibition. Standard therapies such as gemcitabine, 5-fluorouracil (5-FU), doxorubicin and gamma-irradiation directly or indirectly target nucleotide biosynthesis, creating stress that is relieved by scavenged nucleotides. Strikingly, necrotic debris also render macropinocytic, but not non-macropinocytic, pancreas and breast cancer cells resistant to these treatments. Selective, genetic inhibition of macropinocytosis confirms that necrocytosis both supports tumor growth and limits the effectiveness of 5-FU in vivo. Therefore, this study establishes necrocytosis as a mechanism for drug resistance.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Finicle, Bt" uniqKey="Finicle B">BT Finicle</name></author><author><name sortKey="Jayashankar, V" uniqKey="Jayashankar V">V Jayashankar</name></author><author><name sortKey="Edinger, Al" uniqKey="Edinger A">AL Edinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kimmelman, Ac" uniqKey="Kimmelman A">AC Kimmelman</name></author><author><name sortKey="White, E" uniqKey="White E">E White</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Sm" uniqKey="Kim S">SM Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Commisso, C" uniqKey="Commisso C">C Commisso</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Palm, W" uniqKey="Palm W">W Palm</name></author><author><name sortKey="Araki, J" uniqKey="Araki J">J Araki</name></author><author><name sortKey="King, B" uniqKey="King B">B King</name></author><author><name sortKey="Dematteo, Rg" uniqKey="Dematteo R">RG DeMatteo</name></author><author><name sortKey="Thompson, Cb" uniqKey="Thompson C">CB Thompson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Amyere, M" uniqKey="Amyere M">M Amyere</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Araki, N" uniqKey="Araki N">N Araki</name></author><author><name sortKey="Johnson, Mt" uniqKey="Johnson M">MT Johnson</name></author><author><name sortKey="Swanson, Ja" uniqKey="Swanson J">JA Swanson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Davidson, Sm" uniqKey="Davidson S">SM Davidson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kamphorst, Jj" uniqKey="Kamphorst J">JJ Kamphorst</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Palm, W" uniqKey="Palm W">W Palm</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nik Zainal, S" uniqKey="Nik Zainal S">S Nik-Zainal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walker, Ra" uniqKey="Walker R">RA Walker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gilchrist, Kw" uniqKey="Gilchrist K">KW Gilchrist</name></author><author><name sortKey="Gray, R" uniqKey="Gray R">R Gray</name></author><author><name sortKey="Fowble, B" uniqKey="Fowble B">B Fowble</name></author><author><name sortKey="Tormey, Dc" uniqKey="Tormey D">DC Tormey</name></author><author><name sortKey="Taylor, Sgt" uniqKey="Taylor S">SGt Taylor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vander Heiden, Mg" uniqKey="Vander Heiden M">MG Vander Heiden</name></author><author><name sortKey="Deberardinis, Rj" uniqKey="Deberardinis R">RJ DeBerardinis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brown, Kk" uniqKey="Brown K">KK Brown</name></author><author><name sortKey="Spinelli, Jb" uniqKey="Spinelli J">JB Spinelli</name></author><author><name sortKey="Asara, Jm" uniqKey="Asara J">JM Asara</name></author><author><name sortKey="Toker, A" uniqKey="Toker A">A Toker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Levy, Jmm" uniqKey="Levy J">JMM Levy</name></author><author><name sortKey="Towers, Cg" uniqKey="Towers C">CG Towers</name></author><author><name sortKey="Thorburn, A" uniqKey="Thorburn A">A Thorburn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Salloum, Gilbert" uniqKey="Salloum G">Gilbert Salloum</name></author><author><name sortKey="Jakubik, Charles T" uniqKey="Jakubik C">Charles T. Jakubik</name></author><author><name sortKey="Erami, Zahra" uniqKey="Erami Z">Zahra Erami</name></author><author><name sortKey="Heitz, Samantha D" uniqKey="Heitz S">Samantha D. Heitz</name></author><author><name sortKey="Bresnick, Anne R" uniqKey="Bresnick A">Anne R. Bresnick</name></author><author><name sortKey="Backer, Jonathan M" uniqKey="Backer J">Jonathan M. Backer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koivusalo, M" uniqKey="Koivusalo M">M Koivusalo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tajiri, H" uniqKey="Tajiri H">H Tajiri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gustin, Jp" uniqKey="Gustin J">JP Gustin</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Szu Wei" uniqKey="Lee S">Szu-Wei Lee</name></author><author><name sortKey="Zhang, Yijuan" uniqKey="Zhang Y">Yijuan Zhang</name></author><author><name sortKey="Jung, Michael" uniqKey="Jung M">Michael Jung</name></author><author><name sortKey="Cruz, Nathalia" uniqKey="Cruz N">Nathalia Cruz</name></author><author><name sortKey="Alas, Basheer" uniqKey="Alas B">Basheer Alas</name></author><author><name sortKey="Commisso, Cosimo" uniqKey="Commisso C">Cosimo Commisso</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Horisawa, K" uniqKey="Horisawa K">K Horisawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Landgraf, P" uniqKey="Landgraf P">P Landgraf</name></author><author><name sortKey="Antileo, Er" uniqKey="Antileo E">ER Antileo</name></author><author><name sortKey="Schuman, Em" uniqKey="Schuman E">EM Schuman</name></author><author><name sortKey="Dieterich, Dc" uniqKey="Dieterich D">DC Dieterich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hodakoski, Cindy" uniqKey="Hodakoski C">Cindy Hodakoski</name></author><author><name sortKey="Hopkins, Benjamin D" uniqKey="Hopkins B">Benjamin D. Hopkins</name></author><author><name sortKey="Zhang, Guoan" uniqKey="Zhang G">Guoan Zhang</name></author><author><name sortKey="Su, Taojunfeng" uniqKey="Su T">Taojunfeng Su</name></author><author><name sortKey="Cheng, Zhe" uniqKey="Cheng Z">Zhe Cheng</name></author><author><name sortKey="Morris, Roxanne" uniqKey="Morris R">Roxanne Morris</name></author><author><name sortKey="Rhee, Kyu Y" uniqKey="Rhee K">Kyu Y. Rhee</name></author><author><name sortKey="Goncalves, Marcus D" uniqKey="Goncalves M">Marcus D. Goncalves</name></author><author><name sortKey="Cantley, Lewis C" uniqKey="Cantley L">Lewis C. Cantley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Slawson, C" uniqKey="Slawson C">C Slawson</name></author><author><name sortKey="Copeland, Rj" uniqKey="Copeland R">RJ Copeland</name></author><author><name sortKey="Hart, Gw" uniqKey="Hart G">GW Hart</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vocadlo, Dj" uniqKey="Vocadlo D">DJ Vocadlo</name></author><author><name sortKey="Hang, Hc" uniqKey="Hang H">HC Hang</name></author><author><name sortKey="Kim, Ej" uniqKey="Kim E">EJ Kim</name></author><author><name sortKey="Hanover, Ja" uniqKey="Hanover J">JA Hanover</name></author><author><name sortKey="Bertozzi, Cr" uniqKey="Bertozzi C">CR Bertozzi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, X" uniqKey="Yang X">X Yang</name></author><author><name sortKey="Qian, K" uniqKey="Qian K">K Qian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, X" uniqKey="Gao X">X Gao</name></author><author><name sortKey="Hannoush, Rn" uniqKey="Hannoush R">RN Hannoush</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jones, Sf" uniqKey="Jones S">SF Jones</name></author><author><name sortKey="Infante, Jr" uniqKey="Infante J">JR Infante</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alwarawrah, Y" uniqKey="Alwarawrah Y">Y Alwarawrah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hardwicke, Ma" uniqKey="Hardwicke M">MA Hardwicke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Watt, Matthew J" uniqKey="Watt M">Matthew J. Watt</name></author><author><name sortKey="Clark, Ashlee K" uniqKey="Clark A">Ashlee K. Clark</name></author><author><name sortKey="Selth, Luke A" uniqKey="Selth L">Luke A. Selth</name></author><author><name sortKey="Haynes, Vanessa R" uniqKey="Haynes V">Vanessa R. Haynes</name></author><author><name sortKey="Lister, Natalie" uniqKey="Lister N">Natalie Lister</name></author><author><name sortKey="Rebello, Richard" uniqKey="Rebello R">Richard Rebello</name></author><author><name sortKey="Porter, Laura H" uniqKey="Porter L">Laura H. Porter</name></author><author><name sortKey="Niranjan, Birunthi" uniqKey="Niranjan B">Birunthi Niranjan</name></author><author><name sortKey="Whitby, Sarah T" uniqKey="Whitby S">Sarah T. Whitby</name></author><author><name sortKey="Lo, Jennifer" uniqKey="Lo J">Jennifer Lo</name></author><author><name sortKey="Huang, Cheng" uniqKey="Huang C">Cheng Huang</name></author><author><name sortKey="Schittenhelm, Ralf B" uniqKey="Schittenhelm R">Ralf B. Schittenhelm</name></author><author><name sortKey="Anderson, Kimberley E" uniqKey="Anderson K">Kimberley E. Anderson</name></author><author><name sortKey="Furic, Luc" uniqKey="Furic L">Luc Furic</name></author><author><name sortKey="Wijayaratne, Poornima R" uniqKey="Wijayaratne P">Poornima R. Wijayaratne</name></author><author><name sortKey="Matzaris, Maria" uniqKey="Matzaris M">Maria Matzaris</name></author><author><name sortKey="Montgomery, Magdalene K" uniqKey="Montgomery M">Magdalene K. Montgomery</name></author><author><name sortKey="Papargiris, Melissa" uniqKey="Papargiris M">Melissa Papargiris</name></author><author><name sortKey="Norden, Sam" uniqKey="Norden S">Sam Norden</name></author><author><name sortKey="Febbraio, Maria" uniqKey="Febbraio M">Maria Febbraio</name></author><author><name sortKey="Risbridger, Gail P" uniqKey="Risbridger G">Gail P. Risbridger</name></author><author><name sortKey="Frydenberg, Mark" uniqKey="Frydenberg M">Mark Frydenberg</name></author><author><name sortKey="Nomura, Daniel K" uniqKey="Nomura D">Daniel K. Nomura</name></author><author><name sortKey="Taylor, Renea A" uniqKey="Taylor R">Renea A. Taylor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Salic, A" uniqKey="Salic A">A Salic</name></author><author><name sortKey="Mitchison, Tj" uniqKey="Mitchison T">TJ Mitchison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koc, A" uniqKey="Koc A">A Koc</name></author><author><name sortKey="Wheeler, Lj" uniqKey="Wheeler L">LJ Wheeler</name></author><author><name sortKey="Mathews, Ck" uniqKey="Mathews C">CK Mathews</name></author><author><name sortKey="Merrill, Gf" uniqKey="Merrill G">GF Merrill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buj, R" uniqKey="Buj R">R Buj</name></author><author><name sortKey="Aird, Km" uniqKey="Aird K">KM Aird</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Christopherson, Ri" uniqKey="Christopherson R">RI Christopherson</name></author><author><name sortKey="Lyons, Sd" uniqKey="Lyons S">SD Lyons</name></author><author><name sortKey="Wilson, Pk" uniqKey="Wilson P">PK Wilson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guo, Jy" uniqKey="Guo J">JY Guo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shuvalov, O" uniqKey="Shuvalov O">O Shuvalov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parker, Wb" uniqKey="Parker W">WB Parker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sanli, T" uniqKey="Sanli T">T Sanli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sanli, T" uniqKey="Sanli T">T Sanli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matthews, H" uniqKey="Matthews H">H Matthews</name></author><author><name sortKey="Ranson, M" uniqKey="Ranson M">M Ranson</name></author><author><name sortKey="Kelso, Mj" uniqKey="Kelso M">MJ Kelso</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Poillet Perez, L" uniqKey="Poillet Perez L">L Poillet-Perez</name></author><author><name sortKey="White, E" uniqKey="White E">E White</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Edwards, M" uniqKey="Edwards M">M Edwards</name></author><author><name sortKey="Liang, Y" uniqKey="Liang Y">Y Liang</name></author><author><name sortKey="Kim, T" uniqKey="Kim T">T Kim</name></author><author><name sortKey="Cooper, Ja" uniqKey="Cooper J">JA Cooper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Redelman Sidi, G" uniqKey="Redelman Sidi G">G Redelman-Sidi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Labi, V" uniqKey="Labi V">V Labi</name></author><author><name sortKey="Erlacher, M" uniqKey="Erlacher M">M Erlacher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, Q" uniqKey="Huang Q">Q Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Richards, Ch" uniqKey="Richards C">CH Richards</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maiorano, E" uniqKey="Maiorano E">E Maiorano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Richards, Ch" uniqKey="Richards C">CH Richards</name></author><author><name sortKey="Mohammed, Z" uniqKey="Mohammed Z">Z Mohammed</name></author><author><name sortKey="Qayyum, T" uniqKey="Qayyum T">T Qayyum</name></author><author><name sortKey="Horgan, Pg" uniqKey="Horgan P">PG Horgan</name></author><author><name sortKey="Mcmillan, Dc" uniqKey="Mcmillan D">DC McMillan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nofal, M" uniqKey="Nofal M">M Nofal</name></author><author><name sortKey="Zhang, K" uniqKey="Zhang K">K Zhang</name></author><author><name sortKey="Han, S" uniqKey="Han S">S Han</name></author><author><name sortKey="Rabinowitz, Jd" uniqKey="Rabinowitz J">JD Rabinowitz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wellen, Ke" uniqKey="Wellen K">KE Wellen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nahta, R" uniqKey="Nahta R">R Nahta</name></author><author><name sortKey="Hortobagyi, Gn" uniqKey="Hortobagyi G">GN Hortobagyi</name></author><author><name sortKey="Esteva, Fj" uniqKey="Esteva F">FJ Esteva</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Santarpia, M" uniqKey="Santarpia M">M Santarpia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yuan, H" uniqKey="Yuan H">H Yuan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Steelman, Ls" uniqKey="Steelman L">LS Steelman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brown, Kk" uniqKey="Brown K">KK Brown</name></author><author><name sortKey="Toker, A" uniqKey="Toker A">A Toker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Galmarini, Cm" uniqKey="Galmarini C">CM Galmarini</name></author><author><name sortKey="Mackey, Jr" uniqKey="Mackey J">JR Mackey</name></author><author><name sortKey="Dumontet, C" uniqKey="Dumontet C">C Dumontet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Valvezan, Aj" uniqKey="Valvezan A">AJ Valvezan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Halbrook, Cj" uniqKey="Halbrook C">CJ Halbrook</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Franklin, Da" uniqKey="Franklin D">DA Franklin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chhipa, Rr" uniqKey="Chhipa R">RR Chhipa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, S" uniqKey="Liu S">S Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Davidson, Sm" uniqKey="Davidson S">SM Davidson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rebecca, Vw" uniqKey="Rebecca V">VW Rebecca</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boone, Ba" uniqKey="Boone B">BA Boone</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, Jj" uniqKey="Zhao J">JJ Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liang, Y" uniqKey="Liang Y">Y Liang</name></author><author><name sortKey="Niederstrasser, H" uniqKey="Niederstrasser H">H Niederstrasser</name></author><author><name sortKey="Edwards, M" uniqKey="Edwards M">M Edwards</name></author><author><name sortKey="Jackson, Ce" uniqKey="Jackson C">CE Jackson</name></author><author><name sortKey="Cooper, Ja" uniqKey="Cooper J">JA Cooper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sarbassov, Dd" uniqKey="Sarbassov D">DD Sarbassov</name></author><author><name sortKey="Guertin, Da" uniqKey="Guertin D">DA Guertin</name></author><author><name sortKey="Ali, Sm" uniqKey="Ali S">SM Ali</name></author><author><name sortKey="Sabatini, Dm" uniqKey="Sabatini D">DM Sabatini</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Edinger, Aimee L" sort="Edinger, Aimee L" uniqKey="Edinger A" first="Aimee L." last="Edinger">Aimee L. Edinger</name><name sortKey="Jayashankar, Vaishali" sort="Jayashankar, Vaishali" uniqKey="Jayashankar V" first="Vaishali" last="Jayashankar">Vaishali Jayashankar</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/an2020/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000117 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/an2020/Analysis/biblio.hfd -nk 000117 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= an2020
|étape= Analysis
|type= RBID
|clé= PMC:7048872
|texte= Macropinocytosis confers resistance to therapies targeting cancer anabolism
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/an2020/Analysis/RBID.i -Sk "pubmed:32111826" \
| HfdSelect -Kh $EXPLOR_AREA/Data/an2020/Analysis/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |